Published Research Papers

Regenexx stem cell procedures have been studied extensively for more than a decade and our patients are part of the world’s largest human mesenchymal stem cell re-implantation database for orthopedic purposes. We are the only orthopedic stem cell providers with this volume of data to draw upon and to regularly summarize outcome data from our patient registry and make it available to the public.

Regenexx Published Research

• Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration.
  Journal of Translational Medicine
• Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentrationdependent manner
  Bone & Joint Research
• Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration.
  Journal of Translational Medicine
• Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner.
  Bone & Joint Research. (2019)
• A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis; a randomized control trial with 2 year follow-up.
  Journal of Translational Medicine
• A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
  International Orthopaedics
• Symptomatic anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow concentrate and platelet products: a non-controlled registry study.
  Journal of Translational Medicine (2018)
• Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy.
  Journal of Translational Medicine (2017)
• The use of lumbar epidural injection of platelet lysate for treatment of radicular pain.
  Journal of Experimental Orthopaedics (2017)
• A New Atlanto-Occipital (C0-C1) Joint Injection Technique
  Pain Medicine (2017)
• Interventional Orthopedics in Pain Medicine Practice
  Techniques in Regional Anesthesia and Pain Management
• Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study.
  Journal of Translational Medicine (2016)
• Performing a Better Bone Marrow Aspiration.
  Physical Medicine and Rehabilitation Clinics of North America (2016)
• A Dose Response Analysis of a Specific Bone Marrow Concentrate Treatment Protocol for Knee Osteoarthritis.
  BMC Musculoskeletal Disorders (2015)
• Anterior Cruciate Ligament (ACL) Tears treated with Percutaneous Injection of Autologous Bone Marrow Nucleated Cells: A Case Series.
  Journal of Pain Research 2015: 8: 437-447
• Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritis of the Hip; Treatment Registry Results for 196 Patients.
  Stem Cell Research and Therapy; Volume 4: Issue 10; 2014, Article ID 370621,. Centeno CJ.
• Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft.
  BioMed Research International; Volume 2014, Article ID 370621,. Centeno CJ.
• A Prospective Multi-site Registry Study of a Specific Protocol of Autologous Bone Marrow Concentrate for the Treatment of Shoulder Rotator Cuff Tears and Osteoarthritis.
  Journal of Pain Research 2015:8 269–276
• Amide-Type Local Anesthetics and Human Mesenchymal Stem Cells: Clinical Implications for Stem Cell Therapy.
  Stem Cells Transl Med. 2014 Jan 16.
• Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
  Regenerative Sciences Inc (RSI), Centeno-Schultz Clinic, Westminster, CO 80020, USA.–Pain Physician. 2008 May-Jun;11(3):343-53.
• Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine.
  PM R. 2014 Jan;6(1):70-7. doi: 10.1016/j.pmrj.2013.08.612. Centeno CJ.
• Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group.
  Wien Med Wochenschr. 2013 Aug 15.
• Safety and Complications Reporting Update on the Re-implantation of Culture-Expanded Mesenchymal Stem Cells using Autologous Platelet Lysate Technique.
  Centeno CJ, Schultz JR, Cheever M, Freeman M, Faulkner S, Robinson B, Hanson R.–Curr Stem Cell Res Ther. 2011 Oct 17.
• A Case Series of Percutaneous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone Marrow Derived, Mesenchymal Stem Cells and Platelet Lysate
  Journal of Bioengineering and Biomedical Science. 2011
• Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.
  J Orthop Res. 2010 Mar 22
• Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique.
  Curr Stem Cell Res Ther. 2010 Mar;5(1):81-93.
• Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells.
  Med Hypotheses. 2008 Dec;71(6):900-8. Epub 2008 Sep 10.
• Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: A case study.
  Pain Physician. 2006 Jul;9(3):253-6.